Table 2.

Fold increase of anti‐αLβ2 mAb induced αLβ2, α4β1 and α4β7 internalization upon anti‐Fc crosslinking

mAb	αLβ2	α4β1	α4β7
Efalizumab	2.60 ± 0.23*	1.02 ± 0.02 (ns)	1.04 ± 0.03 (ns)
R7.1	1.35 ± 0.05 (ns)	1.00 ± 0.05 (ns)	0.97 ± 0.07 (ns)
TS1/22	1.55 ± 0.02*	1.03 ± 006 (ns)	1.02 ± 0.10 (ns)

Note. Mean value ± SEM of six independent experiments using blood samples from different donors are shown. Statistical significance was determined by using one‐way ANOVA.

Abbreviation: ns, not significant.

^* P < .05.

versus control.