Figure 4.

Electrophysiological properties of TRPM3 in human stem cell‐derived sensory neurons (hSCDS) neurons. (a) Time course of inward (at −120 mV) and outward (at +80 mV) whole‐cell currents in hSCDS neurons showing the effects of the TRPM3 agonists pregnenolone sulphate (PS; 40 μM) and CIM0216 (1 μM). (b) Quantification of the amplitude of inward and outward currents activated by PS and CIM0216 (n = 6). (c) IV relationships corresponding to the indicated time points in panel (a). (d) Difference currents illustrate the typical outward rectification of PS‐activated currents and double rectification of CIM0216‐activated currents. (e,f) CIM0216‐activated whole‐cell currents were partially and reversibly inhibited by isosakuranetin (ISOSA; 5 μM) [Colour figure can be viewed at http://wileyonlinelibrary.com]