Figure 2.

Plots showing chronic administration of CBD to wild‐type (WT) and Scn1a ^−/− mice on neonatal welfare (TNW) score and survival. (A) Neonatal welfare score. CBD significantly improved the TNW score in WT mice from P8 to P8.5 compared to the vehicle‐treated WT mice. CBD significantly improved the TNW score in Scn1a ^−/− mice from P12 onwards compared to the vehicle‐treated Scn1a ^−/− mice. Data are expressed as mean ± SEM; data were analysed by a three‐way ANOVA with Bonferroni's post hoc test; ^# P < .05; *P < .05; ^#represents WT vehicle‐treated versus WT CBD‐treated; *represents Scn1a ^−/− vehicle‐treated versus Scn1a ^−/− CBD‐treated. (b) Survival. CBD treatment significantly (P < .05) increased survival compared to the vehicle‐treated Scn1a ^−/− group. Error bars are SEM; data were analysed by Mantel–Cox test