Table 4.
PFS | OS | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||||||
HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
GNRI/sarcopenia risk | ||||||||||||
Low cachexia risk | Ref. | Ref. | Ref. | Ref. | ||||||||
High cachexia risk | 4.308 | 2.915–6.367 | < 0.001 | 2.773 | 1.826–4.212 | < 0.001 | 4.961 | 3.302–7.452 | < 0.001 | 3.348 | 2.169–5.167 | < 0.001 |
BMI (< 23 kg/m2vs. ≥ 23 kg/m2) | 1.016 | 0.691–1.494 | 0.935 | 1.096 | 0.735–1.632 | 0.653 | ||||||
NCCN-IPI | ||||||||||||
Low to Low-intermediate | Ref. | Ref. | Ref. | Ref. | ||||||||
High-intermediate to High | 5.959 | 3.649–9.732 | < 0.001 | 4.342 | 2.580–7.308 | < 0.001 | 6.474 | 3.855–10.874 | < 0.001 | 4.793 | 2.770–8.292 | < 0.001 |
Other clinical variables | ||||||||||||
Sex (male vs. female) | 1.121 | 0.757–1.659 | 0.569 | 1.109 | 0.739–1.664 | 0.619 | ||||||
B-symptoms (present vs. absent) | 2.574 | 1.694–3.913 | < 0.001 | 1.305 | 0.839–2.031 | 0.237 | 2.372 | 1.533–3.671 | < 0.001 | 1.173 | 0.742–1.856 | 0.494 |
Bulky disease (bulky vs. non-bulky) | 0.874 | 0.513–1.490 | 0.621 | 0.810 | 0.459–1.428 | 0.466 |
Abbreviations: PFS progression-free survival, OS overall survival, HR hazard ratio, CI confidence interval, GNRI Geriatric Nutritional Risk Index, BMI body mass index, NCCN-IPI National Comprehensive Cancer Network-International Prognostic Index