Table 4.

Cox regression for PFS and OS

	PFS						OS
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
GNRI/sarcopenia risk
Low cachexia risk	Ref.			Ref.			Ref.			Ref.
High cachexia risk	4.308	2.915–6.367	<  0.001	2.773	1.826–4.212	<  0.001	4.961	3.302–7.452	<  0.001	3.348	2.169–5.167	<  0.001
BMI (<  23 kg/m2vs. ≥ 23 kg/m2)	1.016	0.691–1.494	0.935				1.096	0.735–1.632	0.653
NCCN-IPI
Low to Low-intermediate	Ref.			Ref.			Ref.			Ref.
High-intermediate to High	5.959	3.649–9.732	<  0.001	4.342	2.580–7.308	<  0.001	6.474	3.855–10.874	<  0.001	4.793	2.770–8.292	<  0.001
Other clinical variables
Sex (male vs. female)	1.121	0.757–1.659	0.569				1.109	0.739–1.664	0.619
B-symptoms (present vs. absent)	2.574	1.694–3.913	<  0.001	1.305	0.839–2.031	0.237	2.372	1.533–3.671	<  0.001	1.173	0.742–1.856	0.494
Bulky disease (bulky vs. non-bulky)	0.874	0.513–1.490	0.621				0.810	0.459–1.428	0.466

Abbreviations: PFS progression-free survival, OS overall survival, HR hazard ratio, CI confidence interval, GNRI Geriatric Nutritional Risk Index, BMI body mass index, NCCN-IPI National Comprehensive Cancer Network-International Prognostic Index