Table 2.
Priors to be used in final analysis
| Primary analysis: uninformative | Sensitivity analyses | ||
|---|---|---|---|
| Sceptical | Enthusiastic | ||
| Control cure rate | Beta(4.75, 0.25) | Beta(4.75, 0.25) | Beta(4.75, 0.25) |
| Regimen comparison | N(0, 10,000) | N(−0.05, 0.009) | N(0, 0.009) |
| Strategy comparison | N(0, 10,000) | N(−0.1, 0.0036) | N(0, 0.0036) |
| Ribavirin comparison | N(0, 10,000) | N(0, 0.009) | N(0.05, 0.009) |
The beta prior for the control cure rate has mean 0.95 and variance 0.008
The model will also be adjusted for genotype, which will have the prior N (0, 10,000) in all analyses
N(m,v) is the normal prior with mean m and variance v