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. 2020 May 18;20:229. doi: 10.1186/s12872-020-01491-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The specific metabolites differentially expressed between BAV and TAV patients prior to TAVR. a PLS-DA analysis implied the diverse metabolic patterns between bicuspid aortic stenosis and tricuspid aortic stenosis. b Comparison of all metabolites between BAV and TAV by volcano plot. c Enrichment analysis for these dominant metabolites which separated BAV stenosis participants from TAV stenosis ones (p-value< 0.05). d The expression of metabolites in arginine and proline metabolism pathway between BAV and TAV patients before TAVR (* indicated p-value< 0.05)