Table 4.
Association between 5 SNPs and risk of non-cardia gastric cancer under different genetic models
| Locus | Model | Genotype | Control [n(%)] | Case [n(%)] | OR (95%CI)a | P | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
|
LATS1 rs9393175 |
codominant | G/G | 253 (59.53) | 253 (67.29) | 1 | – | 1092.330 | 1115.760 |
| A/G | 149 (35.06) | 101 (26.86) | 0.696 (0.509–0.949) | 0.022 | ||||
| A/A | 23 (5.41) | 22 (11.26) | 0.906 (0.486–1.683) | 0.753 | ||||
| dominant | G/G | 253 (59.53) | 253 (67.29) | 1 | – | 1090.969 | 1109.713 | |
| A/A + A/G | 172 (40.47) | 123 (32.71) | 0.725 (0.540–0.972) | 0.032 | ||||
| recessive | G/G + A/G | 402 (94.59) | 354 (94.15) | 1 | – | 1095.593 | 1114.337 | |
| A/A | 23 (5.41) | 22 (5.85) | 1.018 (0.551–1.877) | 0.954 | ||||
| overdominant | G/G + A/A | 276 (64.94) | 275 (73.14) | 1 | – | 1090.429 | 1109.173 | |
| A/G | 149 (35.06) | 101 (26.86) | 0.702 (0.516–0.952) | 0.024 | ||||
| log-additive | – | – | – | 0.814 (0.641–1.030) | 0.088 | 1092.663 | 1111.406 | |
|
LATS2 rs558614 |
codominant | T/T | 123 (29.85) | 90 (23.81) | 1 | – | 1081.499 | 1104.859 |
| C/T | 197 (47.82) | 192 (50.79) | 1.287 (0.916–1.812) | 0.147 | ||||
| C/C | 92 (22.33) | 96 (25.40) | 1.375 (0.923–2.052) | 0.118 | ||||
| dominant | T/T | 123 (29.85) | 90 (23.81) | 1 | – | 1079.635 | 1098.323 | |
| C/C + C/T | 289 (70.15) | 288 (76.19) | 1.315 (0.955–1.815) | 0.094 | ||||
| recessive | T/T + C/T | 320 (77.67) | 282 (74.60) | 1 | – | 1081.613 | 1100.301 | |
| C/C | 92 (22.33) | 96 (25.40) | 1.168 (0.838–1.628) | 0.360 | ||||
| overdominant | T/T + C/C | 215 (52.18) | 186 (49.21) | – | – | 1081.954 | 1100.642 | |
| C/T | 197 (47.82) | 192 (50.79) | 1.107 (0.834–1.470) | 0.480 | ||||
| log-additive | – | – | – | 1.176 (0.964–1.436) | 0.111 | 1079.912 | 1098.600 | |
|
LATS2 rs9552315 |
codominant | T/T | 105 (24.82) | 100 (26.46) | 1 | – | 1096.314 | 1119.743 |
| C/T | 207 (48.94) | 195 (51.59) | 1.034 (0.735–1.456) | 0.848 | ||||
| C/C | 111 (26.24) | 83 (21.96) | 0.812 (0.544–1.212) | 0.309 | ||||
| dominant | T/T | 105 (24.82) | 100 (26.46) | 1 | – | 1096.153 | 1114.896 | |
| C/C + C/T | 318 (75.18) | 278 (73.54) | 0.956 (0.693–1.321) | 0.785 | ||||
| recessive | T/T + C/T | 312 (73.76) | 295 (78.04) | 1 | – | 1094.350 | 1113.094 | |
| C/C | 111 (26.24) | 83 (21.96) | 0.795 (0.570–1.104) | 0.172 | ||||
| overdominant | T/T + C/C | 216 (51.06) | 183 (48.41) | 1 | – | 1095.351 | 1114.095 | |
| C/T | 207 (48.94) | 195 (51.59) | 1.144 (0.863–1.516) | 0.350 | ||||
| log-additive | – | – | – | 0.903 (0.740–1.102) | 0.317 | 1095.226 | 1113.970 | |
|
LATS2 rs7317471 |
codominant | C/C | 350 (82.74) | 302 (79.89) | 1 | – | 1097.992 | 1121.421 |
| C/T | 67 (15.84) | 69 (18.25) | 1.188 (0.816–1.729) | 0.368 | ||||
| T/T | 6 (1.42) | 7 (1.85) | 1.386 (0.449–4.402) | 0.566 | ||||
| dominant | C/C | 350 (82.74) | 302 (79.89) | 1 | – | 1096.061 | 1114.804 | |
| C/T + T/T | 73 (17.26) | 76 (20.11) | 1.204 (0.839–1.729) | 0.314 | ||||
| recessive | C/C + C/T | 417 (98.58) | 371 (98.15) | 1 | – | 1096.804 | 1115.547 | |
| T/T | 6 (1.42) | 7 (1.85) | 1.345 (0.437–4.264) | 0.602 | ||||
| overdominant | C/C + T/T | 356 (84.17) | 309 (81.75) | 1 | – | 1096.322 | 1115.065 | |
| C/T | 67 (15.84) | 69 (18.25) | 1.180 (0.812–1.717) | 0.385 | ||||
| log-additive | – | – | – | 1.185 (0.861–1.633) | 0.298 | 1095.993 | 1114.736 | |
|
LATS2 rs9509492 |
codominant | A/A | 161 (37.97) | 180 (47.24) | 1 | – | 1094.648 | 1118.102 |
| A/G | 194 (45.75) | 161 (42.26) | 0.747 (0.552–1.010) | 0.058 | ||||
| G/G | 69 (16.27) | 40 (10.50) | 0.525 (0.333–0.818) | 0.005 | ||||
| dominant | A/A | 161 (37.97) | 180 (47.24) | 1 | – | 1095.087 | 1113.850 | |
| A/G + G/G | 263 (62.03) | 201 (52.76) | 0.688 (0.518–0.915) | 0.010 | ||||
| recessive | A/A + A/G | 355 (83.73) | 341 (89.50) | 1 | – | 1096.241 | 1115.004 | |
| G/G | 69 (16.27) | 40 (10.50) | 0.609 (0.397–0.923) | 0.021 | ||||
| overdominant | A/A + G/G | 230 (54.25) | 220 (57.74) | 1 | – | 1100.815 | 1119.578 | |
| A/G | 194 (45.75) | 161 (42.26) | 0.871 (0.657–1.156) | 0.339 | ||||
| log-additive | – | – | – | 0.731 (0.594–0.897) | 0.003 | 1092.686 | 1111.449 |
aadjusted for gender and age