. 2020 Apr 21;10(10):5511–5515. doi: 10.1021/acscatal.0c01406

Table 1. Optimization of Catalytic Hydrogenation of Benzanilide^a.

entry	cat.	T (°C)	t (h)	solvent	conv. (%)^b	2a (%)^b	3a (%)^b
1	Ru-1	45	20	THF	67	63	62
2	Ru-2	45	20	THF	99	94	91
3	Ru-3	45	20	THF	20	14	12
4	Ru-4	45	20	THF	3	3	2
5	Ru-2	35	20	THF	99	95	91
6	Ru-2	RT^c	20	THF	52	49	47
7	Ru-2	RT	68	THF	97	91	93
8	Ru-2	RT	68	toluene	79	73	75

Reaction conditions: benzanilide (0.5 mmol), cat. (0.5 mol %), t-BuOK (2 mol %), THF (3 mL), H₂ (10 bar at RT), T (as specified, bath temperature), t (as specified).

Conversions and yields are determined by GC with mesitylene as an internal standard.

RT = room temperature (19–24 °C)

Table 1. Optimization of Catalytic Hydrogenation of Benzanilidea.

Table 1. Optimization of Catalytic Hydrogenation of Benzanilide^a.