Table 2.

Differential diagnosis of diarrhea caused by Satoyoshi syndrome

	Similarities with Satoyoshi syndrome	Differences with Satoyoshi syndrome
Celiac sprue	Most frequent in women in the first decades of life. Diarrhea with nutrient malabsorption Immune basis Iron deficiency anemia Weight loss Associated with other conditions such as autoimmune thyroid disease or myasthenia gravis. It can associate with rare manifestations such as infertility, arthralgia, arthropathy or alopecia. Intestinal biopsies with inflammatory infiltrate	Improvement with gluten free diet. Muscle spasm or cramps not present
Drug induced Diarrhea	Diarrhea Duodenitis with inflammatory infiltrate in biopsies	Improvement after drug withdrawal Muscle spasm and alopecia are not present
Inflammatory bowel disease	Diarrhea and weight loss It can be present in young patients	Inflammatory diarrhea, proctitis, bloody diarrhea, tenesmus, perianal fistulas, stenotic or fibrotic alterations osteoarticular involvement in form of migratory and asymmetric polyarthritis. In SS, bone deformities and alterations in the metaphysis are more frequent.
Irritable bowel syndrome	Increased frequency of bowel movements	No signs of malabsorption or malnutrition. Associated with fibromyalgia, chronic fatigue syndrome, chronic back pain, chronic pelvic pain, chronic headache, and temporomandibular joint dysfunction, depression, anxiety
Autoimmune enteropathy	Immune-mediated intestinal mucosal atrophy can be cause of watery diarrhea	Alopecia, muscle spasms and skeletal alterations are nor present in autoimmune enteropathy