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. 2020 May 19;19:92. doi: 10.1186/s12943-020-01213-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — High levels of circMET promote HCC progression a. The expression of circMET in HCC cells was determined by qRT-PCR; b. The expression of circMET in HCCLM3 cells was inhibited, and in HepG2 cells, it was elevated; c. The invasion abilities of HCC cells with silenced or forced expression of circMET were evaluated by a transwell assay. Left, the representative pictures of transwell assay. Right, statistic of transwell assay; d. The migration abilities of HCC cells with silenced or forced expression of circMET were evaluated by the scratch assay; e. Colony formation assays were performed in the indicated cells. Left, representative pictures of colony formation assay. Right, statistic of colony formation assay; f. Proliferation in HCC cells with silenced or forced expression of circMET was assessed by MTT assay; g. The cell cycle in HCC cells with silenced or forced expression of circMET was assessed by FCM