Table 3.
Comparison on maternal plasma TAMO concentration between preeclampsia and control groups
| Group | T2 plasma TMAO (median (Q1, Q3), μg/m3) | TD plasma TMAO (median (Q1, Q3), μg/m3) | Change of TMAO (median (Q1, Q3), μg/m3) |
|---|---|---|---|
| Control (N = 198) | 84.05 (60.44, 113.90) | 134.96 (78.10, 202.15) | 53.71(− 2.60, 115.52) |
| PE (N = 66) | 92.40 (53.80, 126.36) | 151.01 (103.45, 280.48) | 57.47 (8.32, 211.50) |
| Difference with control (95%CI)a | 7.45(− 6.92, 21.83) | 33.25 (8.54, 57.97) | 24.36(−9.11, 57.84) |
| pb | 0.296 | 0.010 | 0.167 |
| EOPE (N = 17) | 72.30 (54.58, 109.66) | 370.00 (132.37, 514.86) | 297.70 (34.63, 454.05) |
| Difference with control (95%CI)a | −2.62(−23.44, 18.19) | 191.25 (52.33,330.16) | 196.49 (63.67, 329.31) |
| pb | 0.791 | < 0.001 | < 0.001 |
| LOPE (N = 49) | 93.30(53.80, 149.00) | 138.71 (101.66, 207.00) | 30.63 (0.00, 122.42) |
| Difference with control (95%CI)a | 12.33(−5.03, 29.70) | 14.55(−11.16, 40.28) | −4.66(−37.17, 27.84) |
| pb | 0.162 | 0.245 | 0.766 |
| Mild PE (N = 41) | 103.45 (53.80, 149.00) | 138.71 (100.68, 207.08) | 34.63(−1.03, 130.69) |
| Difference with control (95%CI)a | 13.71(−6.17, 33.60) | 15.00(−13.00, 43.02) | −3.70(−40.44, 33.04) |
| pb | 0.170 | 0.275 | 0.819 |
| Sever PE (N = 25) | 85.10 (54.60, 109.66) | 168.24 (128.14, 476.65) | 85.23 (27.96, 340.35) |
| Difference with control (95%CI)a | 0.15(−17.69, 17.99) | 78.93 (26.88, 130.98) | 88.10 (21.03, 155.17) |
| pb | 0.976 | 0.002 | 0.006 |
a 95% CIs were estimated with the Hodges-Lehmann method
b Based on Wilcoxon rank-sum test
Abbreviation: TMAO trimethylamine-N-oxide; PE preeclampsia; EOPE early onset preeclampsia; LOPE late onset preeclampsia; T2 the second trimester; TD the time of delivery; Q1 first quartile; Q3 third quartile; CI confident interval