Table 2.
Summary of alkaloids
| Compound subclass | Isolated metabolites | Plasmodial strain (activities) | Plant species (Family), Taxon IDb | Part of the plant studied | Place of harvest (Locality, Country) | Author, references |
|---|---|---|---|---|---|---|
| Aporphines | 1 to 2 | K1 (8.24 and 2.90 μM, respectively) | Annickia kummeriae (Annonaceae), NCBI:txid225831 | Leaves | Amani Nature Reserve, Tanzania | Malebo et al. [58] |
| Furoquinolines | 3a to 6 | FcB1 (from 162.47 to 298.16 μM) | Teclea nobilis (Rutaceae), NCBI:txid1220089 | Fruits and leaves | Kamwenge district, Uganda | Lacroix et al. [59] |
| 7 | Dd2 (IC50 = 35 μM) | Melicope madagascariensis (Rutaceae), NCBI:txid1487113 | Stem bark | Antsasaka forest of Moramanga, Madagascar | Rasamison et al. [60] | |
| Indoles | 8a to 13 and 15 | 3D7 (from 0.41 to 110.58 μM) | Strychnos icaja (Loganiaceae), NCBI:txid1040889 | Stem bark | Bertoua, Cameroon | Tchinda et al. [61] |
| 14 | FCA20 (0.617 μM) | Strychnos icaja (Loganiaceae), NCBI:txid1040889 | Roots | Kasongo-Lunda, DR Congo | Beaufay et al. [62], Frédérich et al. [63] | |
| W2 (0.085 μM) | ||||||
| Indolosesquiterpenes | 16a and 17a | NF54 (7.6 μM and 29.1 μM, respectively) | Polyalthia oliveri (Annonaceae), NCBI:txid105756 | Stem bark | Mount Kala, Cameroon | Kouam et al. [64] |
| Naphthylisoquinolines | 18a and 19a | NF54 (0.043 and 0.055 μM, respectively) | Ancistrocladus sp. (Ancistrocladaceae), NCBI:txid 63071 | Leaves | Mbandaka, DR Congo | Lombe et al. [65] |
| 20a, 21`a, 22a and 23 to 25 | NF54 (from 0.090 to 6.54 μM) | Ancistrocladus ileboensis (Ancistrocladaceae), NCBI:txid1367080 | Leaves and root bark | Bambange, DR Congo | Li et al. [66] | |
| K1 (0.228 μM for compound 19) | ||||||
| 26a, 27a, 28a and 29a | NF54 (from 0.84 to 22.2 μM) | Ancistrocladus ealaensis (Ancistrocladaceae), NCBI:txid714098 | Twigs and leaves | Mbandaka, DR Congo | Tshitenge et al. [67] | |
| K1 (from 1.4 to 8.2 μM) | ||||||
| Protoberberines | 30 to 33 | K1 (from 0.22 to 0.71 μM) | Annickia kummeriae (Annonaceae), NCBI:txid225831 | Leaves | Amani Nature Reserve, Tanzania | Malebo et al. [58] |
| 34 | K1 (IC50 = 318.66 μM) | Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806 | Stem | Tikrom, near Kumasi, Ghana | Gbedema et al. [68] | |
| Pyridinones | 35 | K1 (IC50 = 81.28 μM) | Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806 | Stem | Tikrom, near Kumasi, Ghana | Gbedema et al. [68] |
| Others | 36 | K1 (IC50 = 32.12 μM) | Canthium multiflorum (Rubiaceae), NCBI:txid58501 | Aerial part | Obala, along River Sanaga, Cameroon | Kouam et al. [69] |
aCompounds identified for the first time in the cited publications
bIdentification number of the source species, derived from the NCBI Taxonomy database