Table 6.

Summary of diterpenoids and sesquiterpenoids

Compound subclass	Isolated metabolites	Plasmodial strain (activities)	Plant species (Family), Taxon IDb	Part of the plant studied	Place of harvest (Locality, Country)	Author, references
Clerodane diterpenes	117 to 119	K1 (IC50 values range from 9.59 to 18.41 µM)	Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806	Stem	Tikrom, near Kumasi, Ghana	Gbedema et al. [68]
Daphnane diterpenoids	120	FcB1 (IC50 value = 19.02 µM)	Neoboutonia macrocalyx (Euphorbaceae), NCBI:txid316724	Stem bark	Kibale National Park, Uganda	Namukobe et al. [96]
	121 and 122	D6 (IC50 values = 65.14 and 6.96 µM, respectively)	Neoboutonia macrocalyx (Euphorbaceae), NCBI:txid316724	Stem bark	Kibale National Park, Uganda	Namukobe et al. [93]
		W2 (IC50 values = 57.82 and 4.10 µM, respectively)
Iridoid diterpenoid	123	K1 (IC50 value = 171.68 µM)	Canthium multiflorum (Rubiaceae), NCBI:txid58501	Aerial part	Obala, along River Sanaga, Cameroon	Kouam et al. [69]
Labdane diterpenoids	124	Suppression of Plasmodium berghei at doses of 25, 50 and 100 mg/kg with chemosuppression values of 50.13, 65.58 and 73.16%, respectively.	Otostegia integrifolia (syn: Rydingia integrifolia, Lamiaceae), NCBI:txid483857	Leaves	Chancho, Central Ethiopia	Endale et al. [97]
Norcassane furanoditerpene	125	3D7 (IC50 value = 2.20 μM)	Caesalpinia bonducella (Caesalpiniaceae), NCBI:txid53845	Roots	Dar es Salaam Region, Tanzania	Nondo et al. [98]
		Dd2 (IC50 value = 4.16 μM)
Sesquiterpenoids	126a, 127a, 128a, 129a, and 130a	W2 (IC50 values range from 1.71 to 2.63 µM)	Salacia longipes (Celastraceae), NCBI:txid662028	Seeds	Mount Kala, Cameroon	Mba’ning et al. [99]
	131a	NF54 (IC50 value = 15.69 μM)	Scleria striatinux (Cyperaceae), NCBI:txid1916803	Rhizomes	Oku, Cameroon	Nyongbela et al. [100]
		K1 (IC50 value = 13.54 μM)

^aCompounds identified for the first time in the cited publications

^bIdentification number of the source species, derived from the NCBI Taxonomy database