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(A) Chemical structure of GlaB and vismione E used to generate the pharmacophore model for GLI1 inhibitors. (B) Graphical representation of the five-feature pharmacophoric model for compounds affecting GLI1 protein level. GlaB (ball and stick notation) and vismione E (stick notation) are superimposed. Green spheres are hydrophobic regions (HY); red spheres are hydrogen bond acceptor groups (HBA); the red ring is an aromatic ring feature (RA).
