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Effects of compounds on the transcriptional activity of the endogenous Hedgehog pathway. Quantification of GLI-dependent luciferase reporter assay in HH-responsive NIH3T3 cells treated with 100 nM SAG and the GLI inhibitors GANT-61, GlaB, or compounds (5 μM) for 48 h. Relative luciferase activity was GLI-dependent reporter firefly/renilla control ratios, with cells treated with SAG equated to 100%. *, p < 0.05; **, p < 0.01.
