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. 2020 Mar 25;11(5):832–838. doi: 10.1021/acsmedchemlett.9b00639

Figure 8.

Figure 8

Silencing of GLI1 and GLI2 mitigates the effect of SST0683 and SST0790 on melanoma cell viability. (A) Western blot analysis of GLI1 and GLI2 in A375 cells transduced with LV-c, LV-shGLI1, or LV-shGLI2. HSP90 was used as loading control. (B–D) Effect of SST0683 (B) and SST0790 (C) on viability of A375 melanoma cells transduced as indicated. GlaB was used as a reference compound (D). Cells were treated with DMSO and compounds at the indicated doses for 72 h. Data are shown as mean ± SD of at least three independent experiments.