Scheme 1. Synthesis of Conjugates with Sebacic Linker.
Reaction conditions: (a) (CH3)3SiCHN2, MeOH/PhCH3, rt, 30 h, 95%; (b) DCC, DMAP, CH2Cl2, rt, overnight, 92%; (c) TBAF, THF, rt, 20 h, 93%; (d) drug, DCC, DMAP, CH2Cl2, rt, 26 h, 66–95%.
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