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Reagents and conditions: (a) 4-chlorobutyryl chloride, THF, triethylamine, rt; (b), benzylamine, KI, acetone, rt; (c), N-Boc protected isonipecotic acid, HOBt, DIC, CH2Cl2, rt; (d), TFA, CH2Cl2, 0 °C. (e), benzyl bromide, K2CO3, acetone, rt; (f) Boc2O, THF, rt; (g) semipreparative chiral HPLC.
