Table 1. Inhibition Data of Title Compounds^a.

	IC50 (nM)
Entry	hAChE	hBChE	KihAChE (nM)
(±)-cis-1	36.5 ± 5.4	6250 ± 906	46.6 ± 3.6 (mixed)
(+)-cis-1	380 ± 45	2330 ± 219	93.4 ± 3.2 (mixed)
(−)-cis-1 (MC1420)	19.2 ± 3.0	14100 ± 205	19.1 ± 1.4 (mixed)
4	748 ± 24	181 ± 7	n.d.
6	223 ± 5	21 ± 2%b	n.d.
Donepezil	16.1 ± 2.7	2900 ± 500	12.7 ± 1.0 (mixed)

^aValues are mean ± SEM of three independent experiments; n.d.: not determined.

^b% inhibition at 10 μM.