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. 2020 Apr 9;11(5):889–894. doi: 10.1021/acsmedchemlett.9b00661

Scheme 1. Synthetic Strategy for the Preparation of Target Compounds.

Scheme 1

Reagents and conditions: (i) 4-benzylpiperidine, Br[(CH2)1–4]CN, NaI, K2CO3, DMF, 60 °C, overnight; (ii) LiAlH4, THF, rt, N2; (iii) AgNO3, CH3CN, rt; (iv) EDC, HOBT, CH3CN, rt, 5 h.