Table 1. Cytotoxicity of Largazole, 1, and 2 against U-2OS, Caco-2, and IMR-32 Cell Line.

		Compounda
Cell line	Time	Largazole	1	2
U-2OS	24 h	4.69 ± 0.12	5.71 ± 0.15	6.33 ± 0.10
	48 h	6.43 ± 0.15	6.51 ± 0.15	6.13 ± 0.20
	72 h	6.48 ± 0.10	6.77 ± 0.09	6.00 ± 0.70
CaCo-2	24 h	>2.0	4.95 ± 0.19	5.04 ± 0.24
	48 h	6.12 ± 0.21	7.42 ± 0.14	8.25 ± 0.22
	72 h	7.84 ± 0.09	8.09 ± 0.16	8.35 ± 0.16
IMR-32	24 h	7.46 ± 0.16	7.82 ± 0.17	7.53 ± 0.12
	48 h	7.52 ± 0.14	7.71 ± 0,17	7.21 ± 0,18
	72 h	7.91 ± 0.08	7.92 ± 0.06	7.30 ± 0.14

^aEC₅₀ were determined as described in the Supporting Information; they are the average value of n = 3 independent experiments ± SEM.