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Effects of 1 and 3 as single agents and in combination in U937 (1 at 0.5 and 3 at 50 μM) and RH4 (1 at 0.15 and 3 at 50 μM) cells. Actin (U937) and vinculin (RH4) are used as equal loading. Densitometries for Ac-H3, Ac-tubulin, and H3K27me3 levels, normalized on an internal loading control and then on a vehicle (DMSO), are reported in red.
