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Functional evaluation of PBTZs as DENV NS3–NS5 PPI inhibitors. (A) Schematic diagram of the in vitro DENV NS3–NS5 ELISA interaction assay as previously described.10 (B) Concentration-dependent inhibition of NS3–NS5 interaction by PTBZ 1, 2, 4, and 5. The IC50 values were presented in parentheses as average ± SD obtained from a single experiment in duplicate.
