Table 2. Cell-Based Efficacy of 1, 4, and 5 against DENV1-4 Serotypes.
EC50 (μM)a |
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---|---|---|---|---|
Cpds | DENV1 | DENV2 | DENV3 | DENV4 |
1 | 2.8 ± 0.60 | 2.1 ± 0.22 | 2.8 ± 0.51 | 1.7 ± 0.24 |
4 | 7.0 ± 3.50 | 3.5 ± 0.45 | 7.8 ± 1.67 | 6.9 ± 1.95 |
5 | 3.2 ± 0.72 | 2.9 ± 0.35 | 4.3 ± 2.68 | 5.9 ± 2.65 |
EC50 is the effective concentration that inhibits 50% virus replication as determined by plaque assay against DENV1–4; data is presented as average ± SD from two independent experiments.