. 2020 Mar 30;11(5):991–999. doi: 10.1021/acsmedchemlett.0c00041

Table 1. UV Thermal Melting Changes (ΔT_m) for Small Compound-Quadruplex Complexes and a Control Duplex Sequence^a.

	G4-hTERT, ΔT_m(°C)(T_m= 67 °C)	G4-HTR, ΔT_m(°C)(T_m= 62 °C)	Duplex DNA, ΔT_m(°C)(T_m= 85 °C)
SOP1812	18	10	2
CM03	13	5	2
MM41	>16^b	11	<2

The thermal melting results are averages of two independent trials and are reproducible within ±1 °C. T_m values of these sequences without compounds are listed above.

Thermal melting changes of MM41with G4-hTERT resulted in a nonstandard melting curve. We therefore predicted the ΔT_m value based on the similarity in structures between MM41 and SOP1812.

Table 1. UV Thermal Melting Changes (ΔTm) for Small Compound-Quadruplex Complexes and a Control Duplex Sequencea.

Table 1. UV Thermal Melting Changes (ΔT_m) for Small Compound-Quadruplex Complexes and a Control Duplex Sequence^a.