Table 3. Synergistic Activity with Colistin on Resistant Clinical Isolates and Cytotoxicity of Selected Pyrazole and Phenol (or Methoxy Analogue Thereof) Derivatives.
| MIC
(μg/mL) to restore inhibition in the presence of 2 μg/mL
COL |
||||
|---|---|---|---|---|
| compound | K. pneumoniae SI-004Bo | K. pneumoniae SI-081R | A. baumannii N50 | IC50 (HeLa cells) |
| 16 | >64 | >64 | 2 | 25 |
| 17 | >64 | >64 | 4 | 18 |
| 18 | >64 | 16 | 8 | >60 |
| 20 | >64 | >64 | 32 | >60 |