Table 2. Enzyme Activities for the Active, Synthesized Compounds and Predicted Properties.

Comp	IC50 (DNMT3B) μM	QPlogSa	QPlogPb	ClogPc
33a	45.0	–5.59	2.76	2.86
33f	28.0	–5.20	2.12	2.29
33g	11.0	–4.10	1.59	1.37
33b	10.0	–3.27	1.81	2.35
33h	8.0	–5.56	1.29	0.85

^aQikProp prediction of aqueous solubility, log S. S in mol/L.

^bQikProp and

^cChemDraw predictions of octanol/water partition coefficient.