Table 4. PK Parameters for Compounds 27, 28, and 29 Following i.v. and p.o. Administration in C57BL/6 Mice at 2 mg/kg and 5 mg/kg, Respectively.

	in vivo profiling
ID	t1/2 (h)	Vdss (L/kg)	Cl (mL/min/kg)	%F
25
27	1.4	0.8	33.1	25
28	3.1	1.2	37.1	40
29	1.1	0.8	30.2	26