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| cmpd | R | R′ | n | abIC50 (nM) |
|---|---|---|---|---|
| 19 | CO2H | OH | 1 | 862 ± 158 |
| 20 | CONH2 | OH | 1 | 1558 ± 300 |
| 21 | CONH2 | OH | 3 | 5539 ± 174 |
| 22 | CO2H | O(CH2)2OH | 1 | 3102 ± 424 |
| 23 | CONH2 | O(CH2)2OH | 1 | 2545 ± 357 |
IC50 for TR-FRET KEAP1 binding assay.
IC50 values are the average of at least three individual measurements ± standard deviation.
