Table 1.
Clinicopathological details of patients diagnosed endometrial stromal sarcoma (N = 10).
| LGE-SS | HGE-SS | UUS | ||
|---|---|---|---|---|
| Age: | <45 years to | 1 (20%) | 2 (66.6%) | – |
| >45 years | 4 (80%) | 1 (33.3%) | 2 (100%) | |
| Presentation: | Abnormal uterine bleeding | 4 (80%) | 3 (100%) | 1 (50%) |
| Mass per abdomen | 1 (20%) | – | 1 (50%) | |
| Procedure: | TAH + BSO | 4 (80%) | 3 (100%) | 2 (100%) |
| TAH + BSO + anterior exenteration | 1 (20%) | – | ||
| Morphology | Tongue-like growth pattern, uniform nuclei, spiralling arterioles | Infiltrative border, uniform small round cells | Infiltrative border with necrosis, pleomorphic cells | |
| IHC | CD10: Positive | 5/5 (100%) | 0/3 (0%) | 1/2 (50%) |
| ER: Positive | 4/5 (83.3%) | 0/3 (0%) | 0/2 (0%) | |
| PR: Positive | 4/5 (83.3%) | 0/3 (0%) | 0/2 (0%) | |
| Cyclin D1: positive | 0/5 | 3/3 (100%) | 0/2 (0%) | |
| FISH – JAZF1-SUZ12 | Positive | 2/5(40%) | ND | ND |
| FISH – YWHAE-FAM22 | Positive | ND | 3/3 (100%) | 0/2 (0%) |
Abbreviations: CD10, cluster differentiation 10; ER, oestrogen receptor; HGESS: high-grade endometrial stromal sarcoma; FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; LGESS: low-grade endometrial stromal sarcoma; ND, not done; PR, progesterone receptor; TAH + BSO, total abdominal hysterectomy with bilateral salpingo-oophorectomy; UUS, undifferentiated uterine sarcoma.