Table 1:

Baseline Characteristics for Patients Undergoing Hysterectomy by Perioperative Opioid Prescription Fill.

Characteristic	Perioperative Opioids	No Perioperative Opioids	ASMD*
Total	N=331,322	N=61,775
Age (years) at Index Procedure, mean±SD	46.6±9.2	50.0±11.5	0.33
Age Category (years)
18–25	486 (0.1%)	143 (0.2%)	0.02
25–34	23,161 (7.0%)	3,095 (5.0%)	0.08
35–44	122,886 (37.1%)	17,729 (28.7%)	0.18
45–54	129,740 (39.2%)	23,245 (37.6%)	0.03
55–64	41,723 (12.6%)	10,779 (17.4%)	0.14
65–74	9,721 (2.9%)	4,138 (6.7%)	0.18
75+	3,605 (1.1%)	2,646 (4.3%)	0.20
Route of Hysterectomy
Abdominal	112,408 (33.9%)	21,103 (34.2%)	0.01
Laparoscopic	163,724 (49.4%)	28,293 (45.8%)	0.07
Vaginal	55,190 (16.7%)	12,379 (20.0%)	0.09
Diagnoses (30 days prior)
Benign Neoplasm	199,666 (60.3%)	35,180 (56.9%)	0.07
Inflammatory Pelvic Disease	99,347 (30.0%)	17,049 (27.6%)	0.05
Endometriosis	104,401 (31.5%)	17,054 (27.6%)	0.09
Prolapse	56,717 (17.1%)	12,227 (19.8%)	0.07
Menstrual Disorders	190,783 (57.6%)	29,780 (48.2%)	0.19
Region
Midwest	78,287 (23.6%)	15,861 (25.7%)	0.05
Northeast	32,884 (9.9%)	8,900 (14.4%)	0.14
South	164,455 (49.6%)	27,202 (44.0%)	0.11
West	51,902 (15.7%)	9,128 (14.8%)	0.03
Unknown	3,794 (1.1%)	684 (1.1%)	0.00
Year
2005	22,869 (6.9%)	5,007 (8.1%)	0.05
2006	21,524 (6.5%)	4,496 (7.3%)	0.03
2007	23,082 (7.0%)	4,414 (7.1%)	0.01
2008	29,858 (9.0%)	5,737 (9.3%)	0.01
2009	34,919 (10.5%)	6,464 (10.5%)	0.00
2010	34,163 (10.3%)	6,203 (10.0%)	0.01
2011	38,233 (11.5%)	7,426 (12.0%)	0.02
2012	39,902 (12.0%)	7,970 (12.9%)	0.03
2013	33,750 (10.2%)	5,729 (9.3%)	0.03
2014	33,874 (10.2%)	5,443 (8.8%)	0.05
2015	19,148 (5.8%)	2,886 (4.7%)	0.05
Charlson Comorbidity Index mean±SD	0.3±0.98	0.5±1.29	0.15
Surgical Details
Inpatient	174,586 (52.7%)	34,983 (56.6%)	0.08
LOS, mean±SD	0.3±1.7	0.3±2.0	0.02
Surgical complication	26,946 (8.1%)	5,704 (9.2%)	0.04
Baseline Non-Opioid Analgesic	46,506 (14.0%)	7,385 (12.0%)	0.06

^*ASMDs below 0.10 are considered negligible.

ASMD=Absolute standardized mean difference, LOS= length of stay