Table 2.

LncRNAs implicated in SSc.

LncRNAs	Modification	Cell type/tissue	Effect	References
CTBP1-AS2, AGAP2-AS1	↑	Skin	Differentially expressed between SSc patients and healthy controls	Messemaker et al.67
OTUD6B-AS1	↓	Fibroblasts, skin	Differentially expressed between SSc patients and healthy controls; antiapoptotic	Messemaker et al.67
				Takata et al.68
ncRNA00201	↓	PBMCs	Regulates genes and pathways involved in vasculopathy, fibrosis and autoimmunity	Dolcino et al.69
NRIR	↑	Monocytes	Aberrant IFN response	Mariotti et al.70
TSIX (X chromosome)	↑	Fibroblasts, serum	Profibrotic	Wang et al.72

LncRNA, long non-coding RNA; NRIR, negative regulator of the IFN response; PBMC, peripheral blood mononuclear cell; SSc, systemic sclerosis.