Table 2.
Associations of protein levels with echocardiographic traits in multivariable-adjusted models in FHS
| ln(LV Mass) | LV Diastolic Dimension | Left Atrial Diameter | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Protein | β est. | SE | P-value | FDR | β est. | SE | P-value | FDR | β est. | SE | P-value | FDR |
| IGFBP-2* | 0.037 | 0.008 | 2.2E-06 | 0.003 | 0.063 | 0.015 | 0.00005 | 0.03 | ||||
| TGF-b R III | 0.023 | 0.006 | 0.00005 | 0.03 | ||||||||
| NT-proBNP* | 0.029 | 0.008 | 0.0001 | 0.04 | 0.061 | 0.015 | 0.00004 | 0.03 | 0.081 | 0.014 | 1.5E-08 | 0.00002 |
| ESAM | 0.022 | 0.006 | 0.0001 | 0.04 | ||||||||
| ART | 0.021 | 0.006 | 0.0002 | 0.04 | ||||||||
| Leptin* | −0.040 | 0.011 | 0.0002 | 0.04 | ||||||||
| Osteopontin* | 0.026 | 0.007 | 0.0003 | 0.05 | ||||||||
| UNC5H3 | 0.020 | 0.006 | 0.0004 | 0.05 | ||||||||
| WFKN1 | −0.021 | 0.006 | 0.0004 | 0.05 | ||||||||
| Epithelial cell kinase | 0.020 | 0.006 | 0.0005 | 0.07 | ||||||||
| RGMC | 0.019 | 0.006 | 0.0007 | 0.08 | ||||||||
| SOD3* | 0.058 | 0.015 | 0.00007 | 0.03 | ||||||||
| HGF | −0.043 | 0.011 | 0.0002 | 0.05 | ||||||||
| MPIF-1 | 0.040 | 0.011 | 0.0002 | 0.05 | ||||||||
| Chromogranin A* | 0.053 | 0.014 | 0.0002 | 0.05 | ||||||||
| Ck-beta-8-1 | 0.037 | 0.011 | 0.0005 | 0.098 | ||||||||
| Dynactin subunit 2* | −0.061 | 0.016 | 0.0001 | 0.06 | ||||||||
Abbreviations: IGFBP-2, insulin-like growth factor-binding protein 2; TGF-b R III, TGF-beta receptor type-3; NT-proBNP, N-terminal proB-type natriuretic peptide; ESAM, endothelial cell-selective adhesion molecule; ART, agouti-related protein; UNC5H3, netrin receptor, UNC5C; WFKN1, WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1; RGMC, repulsive guidance molecule C (hemojuvelin); SOD3, extracellular superoxide dismutase; HGF, hepatocyte growth factor; MPIF-1, myeloid progenitor inhibitory factor 1 (C-C motif chemokine 23)
Protein levels were transformed by rank normalization to mean = 0 and standard deviation = 1 and betas in the table above reflect effect size for a 1 SD increment in transformed and normalized protein levels
Multivariable model is adjusted for age, sex, body mass index, systolic blood pressure, hypertension treatment, total/HDL cholesterol, diabetes, current smoking, and prevalent myocardial infarction
False discovery rate (FDR) value <0.10 was used to determine statistical significance
No proteins were associated with aortic root diameter with FDR <0.10
Protein was measured on the SomaLogic 1.3k platform only (N=1081)