Table 4.

Model discrimination for predicting incident HF with and without proteins associated with HF

	Clinical covariates		Clinical covariates + 5 proteins		Clinical covariates + 6 proteins
	C-statistic	SE	C-statistic	SE	C-statistic	SE
FHS	0.859	0.013	0.872	0.012	--	--
HUNT	0.741	0.020	0.773	0.020	0.800	0.019

Clinical covariates include age, sex, body mass index, hypertension treatment, systolic blood pressure, total/HDL cholesterol, diabetes, smoking, prior myocardial infarction, and interim myocardial infarction

“5 proteins” includes the proteins measured in both batches in FHS: ErbB1, MBL, RGMC, GDF-11/8, TSP2

“6 proteins” includes the 5 proteins listed above + NT-proBNP