Table 1.
Characteristics of SNPs for circulating SHBG concentration from GWAS meta-analysis
| Gene | SNP | Chromosome: position (hg19) | EA | Association with exposure | |
|---|---|---|---|---|---|
| β (SE) | P value | ||||
| PRMT6 | rs17496332 | 1: 107546375 | G | 0.028 (0.0041) | 1.40E−11 |
| GCKR | rs780093 | 2: 27742603 | C | 0.032 (0.0039) | 2.20E−16 |
| BAIAP2L1 | rs3779195 | 7: 97993362 | T | 0.028 (0.0051) | 2.70E−08 |
| ZBTB10 | rs440837 | 8: 81461974 | G | 0.028 (0.0047) | 3.40E−09 |
| JMJD1C | rs7910927 | 10: 65138910 | G | 0.048 (0.0039) | 6.10E−35 |
| SLCO1B1 | rs4149056 | 12: 21331549 | T | 0.029 (0.0052) | 1.90E−08 |
| NR2F2 | rs8023580 | 15: 96708291 | C | 0.030 (0.0044) | 8.30E−12 |
| ZNF652 | rs2411984 | 17: 47445751 | A | 0.033 (0.0044) | 3.50E−14 |
| SHBG | rs12150660 | 17: 7521915 | T | 0.103 (0.0047) | 1.80E−106 |
| SHBG | rs6258 | 17: 7534678 | T | − 0.272 (0.017) | 1.03E−60 |
| SHBG | rs1641537 | 17: 7545721 | C | 0.081 (0.0062) | 8.19E−39 |
| TP53 | rs1625895 | 17: 7578115 | C | 0.052 (0.0067) | 1.17E−14 |
| TDGF3 | rs1573036 | X: 109820068 | T | 0.028 (0.0037) | 4.10E−14 |
Gene nearest gene to SHBG associated SNP, EA effect allele, β per allele effect on SHBG levels, SE standard error, P value P value for the genetic association