Table 2.
Univariate and multivariate analysis for factors related to overall survival using the COX proportional hazard model
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| p-value | HR | 95%CI | p-value | HR | 95%CI | |
| Gender | ||||||
| Female | 0.632 | 0.840 | 0.411–1.716 | |||
| Male | ||||||
| Age | ||||||
| < 50 | 0.926 | 1.034 | 0.511–2.092 | |||
| ≥ 50 | ||||||
| Tumorlocation | ||||||
| 0.661 | ||||||
| Left | 0.642 | 1.247 | 0.491–3.170 | |||
| Rectum | 0.753 | 0.861 | 0.339–2.188 | |||
| Right | ||||||
| TNM | ||||||
| I | 0.000 | 0.000 | ||||
| II | 0.000 | 0.011 | 0.002–0.082 | 0.000 | 0.008 | 0.001–0.097 |
| III | 0.000 | 0.022 | 0.004–0.111 | 0.000 | 0.012 | 0.001–0.138 |
| IV | 0.000 | 0.070 | 0.016–0.306 | 0.000 | 0.047 | 0.011–0.212 |
| Differentiation | ||||||
| Low | 0.231 | 1.547 | 0.757–3.162 | |||
| Moderat and High | ||||||
| Tumor size | ||||||
| < 5 | 0.606 | 0.831 | 0.410–1.681 | |||
| ≥ 5 | ||||||
| Lymph node metastasis | ||||||
| 0.001 | 0.480 | |||||
| N0 | 0.005 | 0.255 | 0.098–0.663 | 0.227 | 3.552 | 0.454–27.791 |
| N1 | 0.718 | 1.174 | 0.492–2.801 | 0.667 | 1.217 | 0.497–2.978 |
| N2 | ||||||
| circ-001971 | ||||||
| High | ||||||
| Low | 0.000 | 6.785 | 2.764–16.654 | 0.001 | 6.456 | 2.060–20.232 |