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Lung function profiles over time. FEV1 (% predicted on the y-axis) is shown against time (age, in years, on the x-axis). Four representative patients are shown with thicker and darker-shaded trajectories, while remaining patients’ trajectories are thinner and in light gray. Two of the selected profiles (which appear lower overall, compared to the other two profiles) correspond to two individuals who experienced pulmonary exacerbations
