Table 1.
Cohort characteristics according to PE onset*
| Characteristic at Baseline | Had PE during follow up (n = 5510) | PE-free during follow up (n = 10,945) | Overall (n = 16,455) |
|---|---|---|---|
| Genotype^ | |||
| Homozygous | 53.0% | 45.6% | 48.1% |
| Heterozygous | 36.4% | 39.1% | 38.2% |
| None/unknown | 10.6% | 15.3% | 13.7% |
| Male sex^ | 47.4% | 53.7% | 51.6% |
| Hispanic | 9.2% | 8.5% | 8.7% |
| Birth cohort^ | |||
| < 1981 | 16.7% | 19.8% | 18.8% |
| 1981–1989 | 31.6% | 22.2% | 25.3% |
| 1990–1994 | 22.0% | 13.9% | 16.6% |
| 1995–1999 | 24.6% | 26.9% | 26.1% |
| > 1999 | 5.1% | 17.2% | 13.2% |
| Age at entry, years^ | 8.7 (6.2–13.0) | 7.9 (6.2–14.0) | 8.2 (6.2–13.6) |
| Low SES | 54.0% | 52.4% | 49.8% |
| MRSA^ | 9.5% | 6.4% | 7.4% |
| Pa^ | 24.2% | 17.3% | 19.6% |
| CFRD^ | 5.1% | 3.2% | 3.9% |
| Pancreatic insufficient^ | 32.3% | 42.3% | 39.0% |
| FEV1, % predicted^ | 83.8 (67.3–98.0) | 93.5 (79.3–105.2) | 90.6 (74.9–103.2) |
| BMIp, percentile^ | 43.1 (19.9–67.0) | 51.1 (27.3–73.4) | 48.6 (24.8–71.3) |
| WFA, percentile^ | 29.1 (10.2–55.0) | 38.9 (16.7–64.7) | 35.5 (14.3–61.7) |
| HFA, percentile^ | 24.5 (8.4–49.8) | 32.4 (12.3–59.5) | 29.7 (10.7–56.7) |
| Length of follow up, years^ | 1.9 (0.5–4.4) | 3.1 (1.0–6.3) | 2.6 (0.8–5.7) |
| Alive^ | 99.9% | 99.7% | 99.8% |
Abbreviations: BMIp body mass index percentile, CFRD cystic fibrosis related diabetes, FEV1 forced expiratory volume in 1 s, HFA height for age, MRSA methicillin-resistant Staphylococcus aureus, Pa Pseudomonas aeruginosa, PE pulmonary exacerbation, SES socioeconomic status, WFA weight for age. * Values at first recorded entry in the database are used for all patients except for follow-up and death; results for continuous and categorical variables are expressed as median (Q1-Q3) and % over column total, respectively. Characteristics marked as ^ imply P < 0.05 for comparison between PE and PE-free groups. Between-group frequencies compared using Chi-square test of independence; continuous variables compared between groups using Welch two-sample t-test