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. 2020 May 18;11:36. doi: 10.1186/s13229-020-00325-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Results of TBSS analysis of FA and RD. Age × group interaction for a FA and b RD, overlaid mean FA computed from all subjects. FA is positively associated with age in both groups but this association is stronger in the autism spectrum condition (ASC) group than in typical controls, whereas RD is negatively associated with age in both groups but this association is stronger in the ASC group than in the control group. Statistically significant voxels are displayed in red-yellow; white matter skeleton voxels are displayed in green, overlaid onto mean FA computed from all subjects. Significance was set at p < 0.05 and was corrected for multiple comparisons with family wise error. Group differences ‘thickened’ and images flipped in the right-left plane for visualization purposes