Table 2. Selectivity Index for Inhibition of Isoforms hCA IX and XII over hCA I and II, for Carboxylic Acids 9a–f and 11a,b.
Cmp | I/IX | II/IX | I/XII | II/XII |
---|---|---|---|---|
9a | >63 | 5 | >29 | 2 |
9b | 36 | 11 | 15 | 5 |
9c | 5 | 4 | ||
9d | 20 | 13 | ||
9e | 42 | 47 | 14 | 16 |
9f | 37 | 13 | 13 | 5 |
11a | 2 | 24 | 10 | |
11b | 5 | 4 | 10 | 7 |