. 2020 Feb 28;11(5):1041–1046. doi: 10.1021/acsmedchemlett.9b00541

Table 2. Kinetic Parameters of Hit Compounds A1H3 and A2H3 to 14-3-3(ζ)^a.

Compd	R_max (RU)	k_on (M^–1s^–1)	k_off (s^–1)	t_1/2 (s)	K_D (μM)
A1H3	4.6 ± 0.2	2.6 ± 0.2 × 10³	4.1 ± 0.1 × 10^–2	17	16 ± 1
A2H3	4.5 ± 0.2	5.8 ± 0.5 × 10²	8.7 ± 0.4 × 10^–3	80	15 ± 1

R_max: maximum analyte binding capacity; k_on: association rate constant; k_off: dissociation rate constant; t_1/2: dissociative half-life; K_D: equilibrium dissociation constant.

Table 2. Kinetic Parameters of Hit Compounds A1H3 and A2H3 to 14-3-3(ζ)a.

Table 2. Kinetic Parameters of Hit Compounds A1H3 and A2H3 to 14-3-3(ζ)^a.