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. 2020 May 12;12:107. doi: 10.3389/fnagi.2020.00107

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Copyright © 2020 Wu, Wu, Wei, Wang, Tian and the Alzheimer’s Disease Neuroimaging Initiative.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The brain region of the insula showing a significant negative correlation with the score of hamilton depression rating scale (HDRS) and logarithmic Clinical Dementia Rating (lnCDR). (B) A significant negative correlation was observed between gray matter volume (GMV) of the insula and the score of HDRS (r = −0.53 and p = 0.015, respectively), which implied that the more the atrophy for the insula, the more severe is the depressive symptom. (C) A significant negative correlation was observed between GMV of the insula and the lnCDR (r = −0.55 and p = 0.012), which implied that the more atrophy for the insula, the more severe is the cognitive impairment.