Table 2.
Partial list of current and potential cancer vaccine modalities
Tumor cells | Protein/molecule-based | Antigen-presenting cells | Vector-based |
---|---|---|---|
Autologous | Protein (HSP) | Unmodified | DNA/RNA |
Allogeneic | Peptide | Apoptotic body loaded | Yeast |
Irradiated | Glycopeptide | Gene modified | |
Oncolysates | Glycolipid mAb fusion proteins | Peptide pulsed RNA transfected | Bacterial: Salmonella |
Gene modified: | Anti-idiotype mAb | Tumor lysate loaded | Listeria |
GM-CSF | Tumor cell fusion | Lactobacillus | |
Costimulatory molecules | |||
Lymphotactin | Viral: Vaccinia Adenovirus RNA replicons Avipox Fowlpox Canarypox MVA |