Table 2.
Partial list of current and potential cancer vaccine modalities
| Tumor cells | Protein/molecule-based | Antigen-presenting cells | Vector-based |
|---|---|---|---|
| Autologous | Protein (HSP) | Unmodified | DNA/RNA |
| Allogeneic | Peptide | Apoptotic body loaded | Yeast |
| Irradiated | Glycopeptide | Gene modified | |
| Oncolysates | Glycolipid mAb fusion proteins | Peptide pulsed RNA transfected | Bacterial: Salmonella |
| Gene modified: | Anti-idiotype mAb | Tumor lysate loaded | Listeria |
| GM-CSF | Tumor cell fusion | Lactobacillus | |
| Costimulatory molecules | |||
| Lymphotactin | Viral: Vaccinia Adenovirus RNA replicons Avipox Fowlpox Canarypox MVA |