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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: JACC Cardiovasc Imaging. 2019 Sep 18;13(1 Pt 2):198–210. doi: 10.1016/j.jcmg.2019.07.018

Central Illustration: Changes in Diastolic Function with Doxorubicin and Trastuzumab Cancer Therapy.

Central Illustration:

Smoothing splines and 95% CIs for change in diastolic parameters according to breast cancer treatment groups. E refers to early mitral inflow peak velocity (cm/sec), e’ to pulse wave tissue Doppler velocity (cm/sec), E/e’ is the average of septal and lateral E/e’, LA to left atrial volume index (mL/BSA). Blue denotes doxorubicin without trastuzumab; Green is trastuzumab without doxorubicin; Purple is doxorubicin and trastuzumab.