Table 2.

Estimated Changes in Diastolic Function Parameters Over Time According to Treatment Regimen

Echocardiographic Parameter	Time since initiation of chemotherapy	Doxorubicin Mean Change (95% CI)	P-value	Trastuzumab Mean Change (95% CI)	P-value	Doxorubicin+ Trastuzumab Mean Change (95% CI)	P-value
E/A	6 months	−0.1 (−0.2, −0.1)	<0.001	0.1 (0.0, 0.2)	0.002	0.1 (0.0, 0.1)	0.067
	12 months	−0.1 (−0.2, −0.1)	<0.001	0.0 (−0.0, 0.1)	0.419	0.1 (0.0, 0.2)	0.012
	24 months	−0.1 (−0.2, −0.1)	<0.001	0.0 (−0.1, 0.1)	0.764	−0.1 (−0.2, −0.0)	0.041
	36 months	−0.1 (−0.2, −0.0)	0.001	0.0 (−0.2, 0.2)	0.923	−0.2 (−0.3, −0.1)	<0.001
Septal e’ (cm/sec)	6 months	−1.0 (−1.3, −0.8)	<0.001	0.6 (0.3, 1.0)	0.001	−0.8 (−1.2, −0.4)	<0.001
	12 months	−1.0 (−14, −0.7)	<0.001	0.1 (−0.4, 0.6)	0.692	−1.0 (−1.4, −0.5)	<0.001
	24 months	−1.1 (−1.4, −0.8)	<0.001	−0.2 (−0.8, 0.4)	0.546	−1.5 (−1.9, −1.1)	<0.001
	36 months	−1.2 (−1.6, −0.8)	<0.001	−0.4 (−1.1, 0.4)	0.331	−1.8 (−2.2, −1.3)	<0.001
Lateral e’ (cm/sec)	6 months	−1.6 (−1.9, −1.3)	<0.001	0.3 (−0.1, 0.7)	0.170	−1.1 (−1.6, −0.6)	<0.001
	12 months	−1.8 (−2.2, −1.4)	<0.001	−0.2 (−0.9, 0.4)	0.517	−1.6 (−2.2, −1.0)	<0.001
	24 months	−1.6 (−2.0, −1.2)	<0.001	−0.1 (−1.1, 0.9)	0.815	−2.0 (−2.8, −1.3)	<0.001
	36 months	−1.5 (−2.0, −1.0)	<0.001	0.1 (−1.0, 1.3)	0.816	−2.3 (−3.2, −1.5)	<0.001
E/e’ average	6 months	0.7 (0.4, 1.0)	<0.001	0.1 (−0.2, 0.5)	0.502	0.9 (0.5, 1.3)	<0.001
	12 months	0.6 (0.3, 1.0)	<0.001	0.1 (−0.3, 0.6)	0.600	1.1 (0.7, 1.6)	<0.001
	24 months	0.5 (0.2, 0.9)	0.001	−0.3 (−0.9, 0.2)	0.195	1.2 (0.6, 1.8)	<0.001
	36 months	0.6 (0.2, 1.0)	0.002	−0.3 (−0.9, 0.3)	0.283	1.3 (0.6, 2.0)	<0.001
LA volume index (mL/BSA)	6 months	−0.9 (−2.1, 0.3)	0.127	3.2 (1.5, 4.8)	<0.001	2.9 (0.7, 5.2)	0.011
	12 months	−2.5 (−4.0, −1.0)	0.001	1.1 (−0.8, 2.9)	0.255	1.9 (−0.5, 4.3)	0.120
	24 months	−4.6 (−5.9, −3.2)	<0.001	−2.5 (−4.9, −0.1)	0.044	−0.8 (−3.7, 2.0)	0.570
	36 months	−5.9 (−7 7 −4 1)	<0.001	−5.3 (−8 2 −2 5)	<0.001	−3.8 (−7 1 −0 6)	0.022

E refers to early mitral inflow peak velocity (cm/sec), A late mitral inflow peak velocity, e’ average mean pulse wave tissue Doppler of the lateral and septal annulus, LA left atrium.