Table 1.
Characteristics of Patients Enrolled by the Studies Composing the International Cystic Fibrosis Gene Modifier Consortium
| Mean Age | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Phase | Study | Site | Total | Unrelated | DF/DF | Female | CFRD | CFRD | No CFRD | Both |
| 1 | TSS | JHU | 285 | 285 | 171 | 147 | 103 | 17.3 | 15.3 | 16 |
| CGS | HSC | 1496 | 1462 | 907 | 819 | 163 | 23.9 | 18.8 | 19.3 | |
| GMS | UNC/CWRU | 1262 | 1247 | 1213 | 674 | 373 | 23.3 | 22.4 | 22.7 | |
| 2 | TSS | JHU | 688 | 403 | 394 | 352 | 149 | 21.5 | 12.4 | 14.4 |
| CGS | HSC | 379 | 351 | 247 | 192 | 55 | 24.4 | 13.4 | 15 | |
| GMS | UNC/CWRU | 740 | 726 | 340 | 403 | 246 | 23.8 | 23.8 | 23.8 | |
| FrGMC | UPMC | 890 | 890 | 588 | 453 | 252 | 24 | 21.2 | 22 | |
| Total phase 1 and 2: | 5740 | 5364 | 3860 | 3040 | 1341 | 23 | 19.1 | 20 | ||
| 2R | TSS | JHU | 591 | 427 | 311 | 267 | 204 | 20.8 | 23.6 | 22.7 |
Abbreviations: 2R, phase 2 replication; CWRU, Case Western Reserve University; DF/DF, individuals homozygous for F508del variant; TSS, Twin and Sibling Study; CGS, Canadian CF Gene Modifier Study; FrGMC, French CF Gene Modifier Consortium; GMS, Genetic Modifier Study; JHU, Johns Hopkins University; HSC, Hospital for Sick Children; UNC, University of North Carolina; UPMC, University of Pierre and Marie Curie.