Table 1.
Studies providing liver-related data.
| Paper | N | Male (%) | Median age | Location | GI symptoms | Underlying liver disease | ALT (U/L) | AST (U/L) | Total bilirubin (uMol/L) |
|---|---|---|---|---|---|---|---|---|---|
| Xu et al. [6] | 62 | 56 | 41 (32–52) | Zhejiang, China | 9% (diarrhea) | 11% | N/A | N/A | N/A |
| Shi et al. [7] | 81 | 52 | 49 (SD 11) | Wuhan, China | 4.5% (diarrhea-vomiting) | 9% | 29.5% (46) | 17% (40.8) | 11 |
| Cao et al. [8] | 199 | 60 | 58 (49–68) | Beijing, China | N/A | 0% | 33 (22–55) | 34 (26–42) | N/A |
| Chen et al. [3] | 99 | 67 | 55 (SD 13) | Wuhan, China | 3% (diarrhea, vomiting) | 39 (22–53) | 34 (26–48) | 15.1 | |
| Wu et al. [9] | 80 | 49 | 46 (30–61) | Jiangzu, China | 2% (vomiting, diarrhea) | 24 (12–38) | 30 (19–39) | 6.6 | |
| Zhao et al. [10] | 19 | 58 | 48 (27–56) | Anhui, China | 5% (diarrhea) | 1% | 36 (11–85) | 34 (17–103) | N/A |
| Chen et al. [11] | 249 | 50 | 51 (36–64) | Shanghai, China | 3% (diarrhea) | 23 (15–33) | 25 (20–33) | N/A | |
| Yang et al. [12] | 52 | 57 | 59 (SD 13) | Wuhan, China | 4% (vomiting) | N/A | N/A | N/A | N/A |
| Pan et al. [13] | 204 | 52.5 | 51.91 (SD 15.98) | Hubei, China | 18% (diarrhea, vomiting, abdominal pain) | 1% | 35.98 (SD 35.82) | 31.36 (SD 25.55) | 13.65 (SD 10.26) |
| Huang et al. [14] | 41 | 73 | 49 (41–58) | Wuhan, China | 2.6% (diarrhea) | 2% | 32 (21–50) | 34 (26–48) | 11.7 (9.5–13.9) |
| Wang et al. [15] | 138 | 54.3 | 56 (42–68) | Wuhan, China | 10%, (nausea, diarrhea, vomiting, abdominal pain) | 2.9% | 24 (16–40) | 31 (24–51) | 9.8 (8.4–14.1) |
| Guan et al. [16] | 1099 | 58.1 | 47 (35–58) | National Health Commission of China | 8.8% (Nausea/vomiting, diarrhea) | 2% | N/A | N/A | N/A |
| Jin et al. [17] | 651 | 50 | 46.14 (SD 14.19) | Health Commission of Zhejiang Province | 11.4% (nausea, emesis, diarrhea) | 10.8% | b25 (15.75–38.47) | b29.35 (20.87–38.62) | b10 (7.15–13.8) |
| Wan et al. [18] | 135 | 53.3 | 47 (36–55) | Northeast Chongqing | Diarrhea 13.3%, Retching 3.0% | 1.5% | 26 (12.9–33.15) | 33.4 (27.8–43.7) | 8.6 (5.9–13.7) |
| aLuo et al. [19] | 183 | 56 | 53.8 | Wuhan, China | N/A | 66.4 ± 13.2 | 65.8 ± 12.7 | N/A |
a
Numbers reported were only in patients that presented with GI symptoms and therefore not included in analysis.
b
Median values in patients without GI symptoms were ALT 21.5 (15–32.8), AST 24.4 (19–32) and bilirubin 9.6 (7.0–13.1). Median age of patients without GI symptoms was 45.09 (SD 14.45) All laboratory data is presented as median (IQR), except for Pan et al., and Luo et al., which are presented as mean ± SD.