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. 2020 May 12;10:700. doi: 10.3389/fonc.2020.00700

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Copyright © 2020 Yang, Ji, Teng, Cai, Wang, Wu, Lei, Lusvarghi, Ambudkar and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structure and the cytotoxic activity of sitravatinib in ABCG2-overexpressing cell lines and their corresponding sensitive cell lines. (A) Chemical structure of sitravatinib. The cell viability-concentration curves for NCI-H460/MX20 and NCI-H460 (B), S1-M1-80 and S1 (C), HEK293 cell lines transfected with full length ABCG2 or empty vector (D) after treatment with serial concentrations of sitravatinib for 72 h. Data are shown as mean ± SD, obtained from at least three experiments performed independently.