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. 2020 May 12;10:700. doi: 10.3389/fonc.2020.00700

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Copyright © 2020 Yang, Ji, Teng, Cai, Wang, Wu, Lei, Lusvarghi, Ambudkar and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug sensitivity of drug-selected ABCG2-overexpressing cell lines to various chemotherapeutic agents in the absence or presence of sitravatinib. The IC₅₀ values of mitoxantrone (A,B), topotecan (C,D), SN-38 (E,F), and cisplatin (G,H) in NCI-H460 and its mitoxantrone-selected resistance cell line (NCI-H460/MX20), S1 and its mitoxantrone-selected resistance cell line (S1-M1-80). Data were collected from independent experiments repeated at least three times and are shown as mean ± SD. *p < 0.05 compared with control group.